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Blood samples were collected on Day 1 and 7 at the following time points: pre-dose, 5 (IV route only) or 30 min (SC route only) and 1, 4, 12, 24, 48, 96, and 144-h post-dose
[11] [4] Preclinical studies have suggested that combining amylin receptor agonism with GLP-1based therapies produces greater reductions in food intake and body weight than either approach in isolation, and early clinical data from the CagriSema programme (cagrilintide combined with semaglutide) has provided some supporting evidence in humans
Typical timeline During the first two to four weeks on the starting dose of 2.5 mg, most patients lose 2 to 5 pounds
He et al., 2019)
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