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These were generally consistent with the known side-effect profile of GLP-1 receptor agonists and were most frequently observed during the dose-escalation phase
Moreover, taking into account numerous clinical studies and experimental data showing that the pathogenesis of depression is not limited to the brain, but may also result from an impaired cross-talk between the central nervous system and other systems in the body, particularly the immune, endocrine and digestive systems, therapeutic GLP-1 analogs such as exendin-4 or liraglutide can also normalize their functioning in many cases, thus preventing the occurrence of maladaptive brain changes associated with depressive symptoms
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Fedecostante M, Onciu OG, Westphal KGC, Masereeuw R (2017) Towards a bioengineered kidney: recellularization strategies for decellularized native kidney scaffolds
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