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Both ultimately raise endogenous growth hormone and IGF-1 levels, placing them mechanistically closer to Tesamorelin than to AOD-9604, which was specifically designed to avoid GH/IGF-1 involvement altogether
employed in osteoarthritis and cartilage regeneration research Pigs Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys 9-month chronic toxicology studies via oral gavage Human subjects Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development
PMID 12086562
