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You better activate your longevity enzymes to survive! Sirtuins: The Pianist That Plays the Genetic Piano NAD+ is the fuel for a class of enzymes/proteins/genes known as sirtuins Sirtuins control whether a cells genetic information is on/off (they regulate gene expression)think of them as the pianist that plays the genetic piano When sirtuins lose function, its as if the pianist becomes demented and starts making a lot of mistakesthis is a primary driver of the aging process Sirtuins become distracted from their primary job (regulating gene expression) by their second job: fixing DNA damage (Thus, DNA damage accelerates aging) Hw do we keep sirtuins active, and thus, slow aging