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Meta-analyses including over 40,000 individuals demonstrate a decreased risk of composite renal outcomes (HR 0.79, 95% CI 0.720.87), confirming renal protection as a class effect independent of cardiovascular advantages (Mavrakanas et al
Base excision repair enzymes like OGG1 and APE1 show increased expression
Anamorelin is the first therapeutic drug in this field and holds the potential to improve the mortality rate and quality of life of cancer patients
Cost variability: Both can be costly
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