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Study outcomes In this large, population-based retrospective cohort study, our primary outcome was to assess the incidence or new-onset of major adverse cardiovascular events categorized as HF, composite cardiovascular events 23,24 , as well as clinically significant portal hypertension events 25

However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer

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GLP-1 analogues have been shown to have cardiovascular benefits and are generally safe for use in individuals with a history of heart disease