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Scientists also found a link between GLP-1 use and an increased risk of arthritic disorders, pancreatitis, sleep disturbances, hypotension, and nephrolithiasis, normally known as kidney stones

Patients should stop the medication and contact their healthcare provider immediately if they experience: Severe or persistent abdominal pain (especially if radiating to the back), which could indicate pancreatitis Persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Yellowing of skin or eyes (jaundice) or pale stools Unexplained fever Severe diarrhoea lasting more than 48 hours Treatment continuation is reviewed regularly, with decisions based on efficacy, tolerability, and ongoing clinical need

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189 An analysis of the bone marrow revealed selective erythroid and slight B-cell hypoplasia