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Patients with a documented history of suicidal ideation or suicide attempts prior to the index date were excluded to minimize potential confounding, because the presence of prior suicidality can indicate a distinct clinical pathway and risk profile that might obscure new-onset events

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The blockade of ERK1/2 activation by U0126 (a MAPK kinases inhibitor) attenuated the IRE1 level, suggesting that ERK1/2 activation causes ER stress activation in PFOS-treated RTCs (Fig