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In a phase 3 study, participants experienced a remarkable weight loss of up to 15% of their initial body weight, showcasing the drugs potential to significantly impact weight management in individuals with Type 2 diabetes

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Fasting insulin and the homeostatic model assessment (HOMA-IR, derived from fasting glucose and insulin) are the most common and practical surrogates, and they are the measures that move so dramatically in the retatrutide trials

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