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We critically evaluate the effectiveness of the approach and give recommendations for evaluation of brain delivery efficacy by transporter-utilizing delivery systems based on CNS pharmacokinetic principles

doi: 10.1016/j.molimm.2025.04.015 34 Samyuktha AarthiSPandiarDSubramanianRKrishnanRP

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demonstrated that both Fer-1 and SRS11-92, specific ferroptosis inhibitors, significantly enhance survival in striatal neurons expressing mutant huntingtin in a dose-dependent manner, providing initial evidence that targeting ferroptosis may offer therapeutic benefits in HD (401)