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Research demonstrates that glutathione is the most abundant biothiol in the liver at approximately 10 mM concentration, where it undergoes conjugation reactions with toxic compounds through glutathione S-transferase (GST) enzymes
Importantly, how ER+ breast cancer cells acquire resistance to ferroptotic insults and whether estrogen plays any role in regulating ferroptosis in ER+ breast cancer remain poorly understood
J Med Virol
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Nature 2011
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