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Also, lowering GSH levels in animals has previously been shown to prevent obesity-related phenotypes in mice, such as weight gain under a high-fat diet 79,80

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Although lifestyle interventions (low-calorie diets and exercise) are still the cornerstone of weight management, weight loss achieved through this approach is extremely difficult to sustain in the long term, particularly due to physiological adaptations that reduce the energy expended or increase appetite to compensate for the missing calories

doi:10.1038/sj.onc.1205638