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C., Ghatei, M
Some novel GLP-1 RAs, such as PT302 and PT320, have data to show that they may reduce levodopa-induced dyskinesia and dopaminergic degeneration, suggesting a potential for synergistic therapy with levodopa
However, evidence for broader benefits remains limited
The GIP receptor activation in tirzepatide may actually moderate some GLP-1-related GI effects, and many users report that tirzepatide is slightly better tolerated gastrointestinally than semaglutide despite being more effective
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