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For researchers exploring alternatives to injectable administration, oral tirzepatide is in development and represents a future where syringe measurements may become less relevant

Among the participants treated with orforglipron in cohort 1, four participants had increased ALT levels greater than or equal to three times the upper limit of normal (ULN) and one participant in cohort 2 and one participant in the placebo group for both cohorts 1 and 2 experienced this elevation in ALT (Extended Data Table 3)

This preserves natural GH function and avoids the desensitization often seen with continuous exogenous human growth hormone

Tirzepatide copies two hormones: GLP-1 and GIP