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Although some of these controversies are clearly based on methodological problems and plain misinterpretation of the data, more recent studies demonstrate that multiple signaling mechanisms dependent on the experimental conditions in animals or specific circumstances in patients, can lead to different modes of APAP-induced cell death, which is the topic of this critical review, which is based on our extensive experience with this topic and the pertinent literature

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Marks are less fine (0.1 mL), so it's a bit less precise for small doses

The most-cited theoretical concern is angiogenesis: both compounds promote new blood vessel formation, which is the intended repair mechanism but also a pathway relevant to tumor growth