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Thus, strategies to boost cell glutathione level are of marked therapeutic significance

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As proteostasis capacity becomes constrained, newly synthesized polypeptides requiring high chaperone support for proper folding may become increasingly vulnerable, rendering neuronal cells more susceptible to damage

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Mutations in SOD1 are considered oxidative stress-inducing factors in ALS pathogenesis

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For example, ketamine is a non-competitive antagonist of the NMDA glutamate receptor, which has been shown to quickly reduce depressive symptoms, anxiety, and PTSD (5761)

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