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J Endocrinol (2002) 172(2):35562
Have you tried your best to lose weight by cutting calories and exercising
Many healthcare providers recommend pausing or carefully reassessing semaglutide use during this time , as further slowing digestion may worsen discomfort or delay recovery
Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied
