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Adults Over 50 Reduced stomach acid production Decreased ability to absorb B12 from food Common medications that interfere with B12 absorption 4

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SDC2 (syndecan 2) is a transmembrane heparan sulfate proteoglycan

Amylin and Cagrilintide activate CGRP-like neurons in the AP that project to: Nucleus tractus solitarius (NTS) , autonomic center Parabrachial nucleus , integration of taste and satiety Hypothalamic pathways , energy balance The result: strong central appetite suppression and stabilization of satiety between meals