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Evidence also suggests it slows kidney disease progression

Central GLP-1 binds to GLP-1 receptor (GLP-1R) to exert many important effects including modulation of energy balance, cardiovascular system, learning and memory, rewarding effect of food, and thermogenesis (Trapp and Cork, 2015)

NICE guidance on osteoarthritis (NG226: Osteoarthritis in over 16s: diagnosis and management) and obesity management (CG189: Obesity: identification, assessment and management) both acknowledge the musculoskeletal benefits of sustained weight loss, including improvements in knee and hip pain

Semaglutide reduces appetite, which means you drink less passively (much of our daily water intake comes from food)