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Description

Copper toxicity, oxidative stress, and antioxidant nutrients

Stimulation of a sympathetic nerve leads to the release of NPY which has stronger vasoconstriction properties than norepinephrine (75)

These biological actions define the counter-balancing catabolic role that glucagon serves relative to insulins anabolic action

Therefore, we hypothesize that deregulated homocysteine metabolism in homocystinuria with severe hyperhomocysteinemia will lead to the cyclization of homocysteine into homocysteine thiolactone, which may render LDL less susceptible to oxidation

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