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In the case of obese individuals, an elevated BMI has been linked to increased interactional displacement, primarily stemming from the continuous movement of the skin and subcutaneous adiposity [31]

In a controlled study, variation in ischemia/reperfusion tolerance across time of day has been previously explored, showing an increase in infarct volume and fibrosis at the onset of activity (ZT12) compared to the beginning of the inactive period (ZT0) in WT mice (Durgan et al., 2010)

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This means it activates two hormone pathways instead of one