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SOUL: CVOT 13 Study design: A randomized, international, double-blind, parallel-group, placebo-controlled, event-driven, superiority phase 3b trial in adults with T2D and established atherosclerotic cardiovascular disease, CKD, or both

However, its metabolic conversion by gut microbiota into TMAO raises significant concerns due to the association of elevated TMAO levels with cardiovascular diseases like atherosclerosis, MI, stroke, and HF

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Do not spray it directly onto the powder, as this can damage the fragile peptide chains