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If AHK-Cu is used at all, the better-evidenced route for its hydrophilic chemistry is topical [5] , and even then it is at most a speculative cosmetic adjunct to an evidence-based plan not a stand-alone solution, and certainly not something the data support injecting

Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity

Some research protocols combine both approaches for maximum metabolic correction

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