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For example, injectable pyridoxine solutions may contain aluminum as a trace impurity, and with prolonged use in patients with renal impairment (especially premature neonates with immature kidneys) there is a risk of aluminum accumulation and toxicity
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(104) studied the effect of temperature on the structures of the insulin monomer, dimer, and hexamer using simulated annealing MD simulations to complement the observations from dynamic light scattering (DLS), CD, and NMR experiments
