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In addition, the brain is susceptible to oxidative stress because its high in fat, which can oxidize or go rancid. The brain is also high in iron and zinc, which can further fuel oxidative stress

Biochem Biophys Res Commun 209:227233 Mulcahy RT, Untawale S, Gipp JJ (1994) Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells