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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial

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Pregnant or nursing individuals should avoid the product

Overall, the use of GLP-1 RAs was not associated with a higher incidence of suicide or suicide attempts in new-user active comparator cohort analyses or in self-controlled case series analyses