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438 Functional MRI studies have reported augmented blood oxygen level-dependent (BOLD) responses in limbic and striatal structures in response to heat pain in PDPN patients
FIGURE 6 5.3.2 Activation of NF-B by ROS promotes inflammation and protein degradation Nuclear factor-B (NF-B) is a key redox-sensitive transcription factor that regulates inflammation, cell survival, and protein catabolism in skeletal muscle (Roy et al., 2018)
Another meta-analysis of 21 trials in overweight and obese individuals found small but significant reductions in body weight (approximately 0.75 kg), BMI, and body fat percentage compared to placebo
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