AFTER MONTH 1, THE DOSAGE PER INJECTION INCREASES GRADUALLY IN MONTH 2, 3, AND 4
(PubMed) Sun J, Rangan P, Bhat SS, Liu L
And for more rapid improvement intramuscular therapy is used, and it must be considered in patients with severe deficiency or severe neurologic symptoms
Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose