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Organ Stress and Toxicity organ-stress-and-toxicity Regulatory bodies and expert clinicians have raised concerns about the potential toxicity to the liver, kidneys, and nervous system

NIH R01HL158555

Differences between groups were compared via two-tailed unpaired t tests for two groups, one-way analysis of variance (ANOVA) followed by Dunnetts multiple comparison test for multiple groups, or two-way repeated-measures ANOVA followed by the Bonferroni multiple comparison test for multiple groups and time courses

Vitamin D correction with high-dose supplementation (50,000 IU weekly for eight to twelve weeks, then maintenance dosing) can normalize levels within three months