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Researchers observed that GHK-Cu influences expression of over 4,000 human genes based on microarray studies, with significant effects on genes involved in collagen synthesis, metalloproteinase regulation, antioxidant defense (SOD, glutathione), and growth factor signaling (TGF-, VEGF, FGF)

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The results showed that, following the injection of GS-AuNPs and saline, the ultrasound signals in both UUO and normal kidneys were weak (Figure S2B)

The compound was first discovered in 2003