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Vegans and vegetarians are particularly at risk for B12 deficiency because plant-based foods do not naturally contain vitamin B12
By inhibiting NNMT, which preserves SAM and NAD+ pools, supports sirtuin activity, and reduces adipocyte lipogenesis
Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells
Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage
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