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Clinically meaningful results are usually observed after 3 to 6 months, where patients may notice steady and sustained fat loss when combined with lifestyle changes such as improved nutrition and physical activity

Other considerations documented for tirzepatide in its FDA labeling include injection-site reactions, decreased appetite, and warnings such as the risk of thyroid C-cell tumors observed in rodents (a boxed warning) and pancreatitis and gallbladder events

Most people find the nausea manageable after the first month

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