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16 detailed answers on GH secretagogues, the somatotropic axis, and research protocols with PubMed references The somatotropic axis is the hypothalamic-pituitary-liver hormonal cascade that regulates the production of growth hormone (GH) and IGF-1 (insulin-like growth factor 1)

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However, NICE guideline NG28 specifies continuation criteria: treatment should be reviewed after approximately 6 months and only continued if you've achieved both a reduction in HbA1c of at least 11 mmol/mol (1%) and weight loss of at least 3%

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