Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a stepwise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg, and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg, and 9 mg)
6C, D), suggesting that, at least in the initial phase of treatment, these compounds drive their weight-lowering effects mostly by reducing food consumption, without inducing thermogenic responses
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