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: bilayer integrity, mechanical strength, swelling and matrix expansion, and layer-specific dissolution all need to be defined deliberately

Similarly, bilayer wound dressings , such as asymmetric polycaprolactone (PCL)hydrogel constructs, demonstrate how spatially organized scaffold architectures can facilitate sequential control over hydration, antioxidant release, and tissue regeneration, reinforcing the value of spatiotemporal design principles in regenerative biomaterials [20]

Maybe you can comment on that aspect and also on the length of our study that we performed

Running these together during a loading phase (especially for joint, tendon, or connective tissue goals) is a well-established protocol