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genetic predisposition, exposure to UVR, pregnancy, and exogenous hormones (i.e., oral contraceptives and hormone replacement therapy)
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The Bottom Line Persistent leg coldness often indicates treatable circulation or metabolic disorders that worsen without proper medical intervention
Inclusion criteria were clinical trials, observational studies (cohort, case control, cross-sectional), and case reports/series involving patients diagnosed with HS treated with GLP-1 RAs
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