Regulatory authorities require manufacturers to demonstrate both efficacy and safety only up to the expiry date
Direct Drug Effect: While less understood, the direct pharmacological action of Ozempic on GLP-1 receptors in the central nervous system may also contribute to feelings of fatigue
With these drugs, the main side effects are nausea, vomiting, constipation, diarrhea, and other gastrointestinal issues
Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ (2013) Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation