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GLP-1 medications slow gastric emptying and reduce appetite, which means you're eating less overall
Their use in these populations has been associated with hemoglobin A1c reduction, significant weight loss, and a decrease in long-term microvascular and macrovascular complications ( This mini-review discusses clinical studies evaluating adjuvant treatment with GLP-1RA in patients with T1D as an opportunity to improve glycemic control, achieve weight loss, and decrease total daily insulin (TDI) requirements in these patients
Recent studies show that sodium-glucose cotransporter 2 (SGLT2) inhibitors can not only protect the kidneys by reducing blood sugar, improving hemodynamics and reducing proteinuria (Martinez Leon et al., 2026), but also inhibit ferroptosis by restoring iron homeostasis, limiting lipid peroxidation and enhancing antioxidant systems (Tsai et al., 2025)
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TP53 also regulates mitochondrial respiration in cancer progression
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