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01 Once-Weekly Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine 2021 peer-reviewed original research (randomized controlled trial) Open source 02 Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity New England Journal of Medicine 2025 peer-reviewed original research (randomized controlled trial) Open source 03 Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes New England Journal of Medicine 2023 peer-reviewed original research (randomized controlled trial) Open source 04 Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes New England Journal of Medicine 2016 peer-reviewed original research (randomized controlled trial) Open source 05 Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes New England Journal of Medicine 2019 peer-reviewed original research (randomized controlled trial) Open source 06 Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis New England Journal of Medicine 2025 peer-reviewed original research (randomized controlled trial, planned interim analysis) Open source 07 Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial Nature Medicine 2024 peer-reviewed original research (secondary/subgroup analysis of RCT) Open source 08 Assessment of Thyroid Carcinogenic Risk and Safety Profile of GLP1-RA Semaglutide (Ozempic) Therapy for Diabetes Mellitus and Obesity: A Systematic Literature Review International Journal of Molecular Sciences 2024 systematic literature review Open source Product FAQ Questions buyers ask about Semaglutide What are Semaglutide's reference identity values?+ The commonly cited free-compound reference is CAS 910463-68-2, PubChem CID 56843331, formula CHNO and average molecular weight about 4113.6 Da

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A., Sherr, A., Shirin, S., Solodkina, G., Morales-Tapia, E., Wolf, B., Lifshitz, Y

Tirzepatide, used in Zepbound and Mounjaro, targets both the GLP-1 and the GIP receptor agonist, while semaglutide, found in Wegovy and Ozempic, mimics only the GLP-1 receptor agonist, a type of hormone in the body that impacts everything from the brain to muscle to the pancreas, stomach and liver