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The physiological response of animals to limited food resources are controlled by interactions of cellular and molecular mechanisms, which drive overall metabolic changes 29
The "central plan" of GLP-1 RA is not limited to individual cells, but also achieves the reconstruction of whole-body energy metabolism through the neuroendocrine immune network: GLP-1 receptors are highly expressed in areas such as the hypothalamus and solitary tract nucleus of the brain, and their activation can inhibit the activity of appetite centers (such as NPY/AgRP neurons), while enhancing the transmission of satiety signals (such as POMC neurons)
The evolving story of GLP-1 RAs and metformin reminds us that a one-size approach risks both suboptimal outcomes and avoidable side effects for women
Advise patients to inform their healthcare provider of a known or suspected pregnancy
