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H.YueL.NakajimaH.TsuboiM.et al (2018)
The concept of the circadian rhythmicity in the human secretion of renin and aldosterone, under the influence of posture, sodium intake and age, is well known from decades ( Hyperglycemia and RAAS in the Kidney High glucose levels in the proximal tubule can cause increased reabsorption of glucose, sodium and water, favored by the upregulation of SGLT2 activity and expression of Na-K-2Cl cotransporter, acquaporin-2, and urea transporters, as reported in diabetic patients ( Accumulated evidence has shown that the RAAS is no longer considered to act just as an endocrine system, but also as a paracrine, autocrine and intracrine system
Similar studies are ongoing in patients with metabolic liver diseases, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), based on the known ability of GLP-1 to reduce fat levels in the liver
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