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Plateaus extending beyond 6 weeks suggest metabolic adaptation requiring medication adjustment or genetic-guided optimization

ArGLP-1 also reduced total mortality (HR 0.88, 95% CI 0.820.94, p = 0.0001) and hospital admission due to heart failure (HR 0.89, 95% CI 0.820.98, p = 0.013), all without increasing the risk of severe hypoglycemia, pancreatic problems or retinopathy.87 A recent post hoc analysis of CVOT with semaglutide has shown a gain in time free of cardiovascular disease of 1.7 years in those patients with CKD vs

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Clinical trials have shown that the 2 mg dose provides approximately 0.2-0.3% additional HbA1c reduction compared to the 1 mg dose