The results of the phase 1 studies of AMG133 could provide insights into the role of GIP receptor antagonism within glucose metabolism, however, determining the exact effect of the GIP receptor antagonism remains challenging due to an anticipated influence of GLP-1 receptor agonism
And our current thinking about obesity, and one of the components of the disease of obesity, is that some individuals although they all have GLP-1 and these other gut hormones, amylin, glucagon, GIP, that's what they're called that signal, for some reason, is not getting to the brain in ample amounts to tell the individual to feel full, satiated, and stop eating
On a GLP-1 medication, most people do better starting with psyllium husk
As seen for the GIP receptor knockout mice, VLP-GIP efficiently reduced body weight gain in animals on a high-fat diet (69), supporting that the GIP receptor plays a role in developing obesity