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Under arsenite stress, this METTL3/YTHDF2 interaction is inhibited, which stabilizes CHAC1 mRNA and increases its expression ( In addition to arsenite-induced expression, the CHAC1 gene is transcriptionally activated during cysteine, serine or arginine depletion (Ward et al., 2024)

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Oral melanotic macules can appear in people of any age, race / ethnicity, and sex