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Lower doses still produced clinically meaningful improvements, but the highest doses essentially de-fatted the liver in the vast majority of participants
So, if you need to give 60 mEq, thatll take 6 hours
This is a real-world, non-randomized study: inevitably subject to selection bias, adherence differences, unbalanced comorbidities, and socioeconomic or prescribing factors that may explain some of the observed differences
Even if you suspect the medication lost some potency, taking more than prescribed carries its own risks, particularly gastrointestinal side effects like constipation or increased burping
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