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Typically, the regimen starts with 0.25mg (5 units) once weekly for the first four weeks, followed by an increase to 0.5mg (10 units) for the next month

Although the findings are not always consistent, changes in the brainstem have been very common, especially structural changes, mainly a decrease in grey or white matter volume in patients, often pronounced in relation to the symptom burden of fatigue, pain and autonomic symptoms

The hormone it releases reduces the thickness of the uterine lining, which means less tissue builds up to shed during a menstrual period

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