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12 This may be in part due to the observation that the aforementioned side effects tend to decrease over time with ongoing treatment, potentially due to tachyphylaxis/tolerance, 13,14 or that patients who experience more severe symptoms related to delayed gastric emptying may stop the medication early

Co-Medication Usage: Patients on any of these medications may also be taking other drugs for pre-existing conditions (e.g., hypertension, diabetes, infections) that are known photosensitizers

While most GI side effects (nausea, vomiting and diarrhoea) caused by GLP-1RAs are mild to moderate and short-lived [5, 6, 50], they can be minimised by recommending simple measures such as eating smaller meals, stopping eating as soon as the patient feels full, and injecting at mealtimes

And remember, you already have too few calories in your system from the GLP-1, which means your blood glucose may already be low, so lowering it even more with extra glucose lowering medications is only going to make matters worse