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PAM variants are also more common in people with diabetes
Long-term studies, like the STEP 5 trial , followed patients for two years and found that most people tolerated semaglutide well, with less than 4% stopping due to side effects
Further, Sanyal noted that retatrutide doses greater than 4 mg improved insulin sensitivity, increased adiponectin and reduced serum triglycerides and leptin compared with placebo
The combination also increases the risk of nausea and can further stress the GI tract during the window when side effects are already most likely
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