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Individuals with kidney disease: Since the kidneys filter toxins from the blood, people with kidney problems may be at increased risk of problems

Practical implementation of the barometric method for measurement of tidal volume

Significant pain, spreading redness, warmth, or swelling that worsens over time may indicate infection and warrants medical attention

Efruxifermin (formerly AKR-001, AMG 876), the only other FGF21 analog studied in a clinical trial of biopsy-confirmed NASH patients, is a 92 kDa Fc-FGF21fusion protein with a 33.5 day half-life (based on intact C-terminal domain of the FGF21 moiety), which is substantially extended relative to the FGF21 analogs described above