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GSH is a small molecule peptide which composed of glutamic acid, glycine and cysteine, and it is the main thiol compound of non-protein in the organization
Environ Health Perspect 118(10):14711475
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo
These, for example, include prodrug strategies, as seen in the case of OTC, which was designed to have improved bioavailability and stability (it is thought of being converted to cysteine intracellularly, which is then used for GSH synthesis) or NAC amide that has improved lipophilicity and cell permeability
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